Article provided by: bosterbio.com
Mutations in the epidermal growth factor receptor, EGFR, often leads to cancer. EGFR antibody allows researchers to study the impact of the receptor and its impact. Bosterbio Antibody and ELISA provides quality and quantity for scientists with fast, no-hassle shipping.
What is EGFR?
EGFR is a transmembrane protein receptor for members of the epidermal growth factor of extracellular protein ligands. Stanley Cohen discovered the presence of EGFR in 1986, receiving a Nobel Prize in Medicine alongside Rita Levi-Montalcini for their discovery of this factor.
The growth factor activates through the binding of specific ligands. It may be constitutively in an active state or become active upon heterodimerization.
Role of EGFR
The growth factor stimulates intracellular protein-tyrosine kinase activity. The phosphorylated receptor recruits adaptor proteins like GRB2, which activates complex downstream signaling.
EGFR stimulates four major downstream signaling cascades. These are RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCGamma-PKC, and STATS modules. Signaling may extend to NF-kappa-B as well. One effect of this process is a role in enhancing learning and memory performance.
Which diseases are EGFR related to?
Due to the ability to impact learning and memory, this growth factor relates directly to Alzheimer’s Disease. Overexpression also relates directly to cancers such as adenocarcinoma of the lung, anal cancer, glioblastoma, and epithelium tumors on the head and neck.
A deficit relates to memory-related diseases. The overabundance of EGFR promotes tumor growth.
Inflammation and wound healing
Researchers discovered links between EGFR and multiple diseases and processes. Aberrant signaling is implicated in psoriasis, eczema, and atherosclerosis, but the exact role remains undefined.
EGFR even helps in healing and fibrosis. The gene plays a role in TGF-beta1 dependent fibroblast to myofibroblast differentiation. The abnormal presence of myofibroblasts leads to progressive tissue fibrosis, which impairs tissue or organ function.
What is the EFGR antibody?
While the growth factor promotes behavior, the antibody suppresses this. The effect allows researchers to examine the role that this growth factor plays in different diseases or conditions.
There is a particularly interesting use case in organ inflammation. A single child lost function mutation in the EGFR gene leading to monogenic disease. In vitro studies resulted in a similar impact. Clinical features included rash, dry skin, abnormal hair growth, and breathing difficulties.
As an oncogene, numerous therapeutics target EGFR. AstraZeneca developed Osimertinib to target tyrosine kinase. Other therapies related to lung and colon cancer.
Antibodies play a crucial role in these studies. They help reduce the expression of EGFR. Studies found up to a 60 percent response rate when using inhibitors.
Where can I find EGFR antibodies?
EGFR antibodies help researchers study the effects of the growth factor. Whether looking for a solution or an over-expression or under-expression of the factor, Bosterbio Antibody and ELISA provides quality solutions fast.
Our ELISA kits and antibodies ship the next day, allowing you to dive into research. We provide polyclonal solutions in quantities of 100 micrograms per vial. If you are looking for EGFR antibodies, we can help. Visit our website today for more information on our numerous offerings.